Public Citizen says its analysis of Food and Drug Administration records show 16 people died after injections with Botox or Myo-bloc, its medical counterpart.
The group says 4 were under the age of 18, and that some reactions were from unapproved, or "off label" uses of the drug.
However, only 1 was a person getting the Botox for cosmetic reasons.
The medication is used fro a variety of conditions, from wrinkles to relieving tight neck muscles.
One expert who researched the drug says Botox is safe - IF the doctor is well-trained.