Moore, 47, has received Oscar nominations for her roles in "Boogie Nights," "The Hours," "The End of the Affair" and "Far From Heaven."
Scalese said the $75 million that state lawmakers approved last year for annual tax incentives for movie production helped in the final decision to shoot in western Pennsylvania.
The tax break has helped lure several productions to the area, said Dawn Keezer, director of the Pittsburgh Film Office.
Kevin Smith is shooting his comedy "Zack and Miri Make a Porno" in the region. Filming of "The Road," starring Charlize Theron and Viggo Mortensen, is scheduled to begin later this month.
"Right now, we're just so incredibly busy and we keep getting calls every day," Keezer said.
