Pennsylvania voters go to the polls April 22 for the primary, a contest with 158 delegates at stake.
Obama also has agreed to a matchup on April 19 hosted by CBS News in North Carolina, his campaign said. North Carolina has 115 delegates up for grabs in its May 6 primary. CBS News said it was awaiting word on whether Clinton would participate.
The contenders have debated 20 times during the presidential campaign.