He didn't start the previous three games against the Phillies because of general soreness, including a bothersome left knee.
Griffey walked as a pinch-hitter in the eighth inning in each of the last two games and pitcher Bronson Arroyo ran for him both times. Fans booed the walks, but cheered when Junior's name was announced before the game.
Griffey entered 0-for-2 with a walk and two strikeouts against Phillies ace Cole Hamels.
The only other players to hit 600 homers are Barry Bonds, Hank Aaron, Babe Ruth, Willie Mays and Sammy Sosa.
