He will undergo reconstructive surgery to repair the anterior cruciate ligament, or ACL, in his left knee.
It was also disclosed that Woods suffers from a double stress fracture of his left tibia, an injury discovered last month before his Open victory.
Woods had surgery to clean out cartilage April 15.
He was in obvious pain at times during the U.S. Open, which he won in a 19-hole playoff Monday over Rocco Mediate.
Woods was last seen in public late Monday afternoon walking with a pronounced limp across Torrey Pines toward the parking lot, the U.S. Open trophy in his arms.
Upcoming surgery makes his 14th major title even more staggering - despite the stress fracture, he managed to win a U.S. Open that required 91 holes over five days.
Woods played only seven times worldwide this year and won six of them.
He will miss a major championship for the first time in his career and will not be available for the Ryder Cup in September.
