Vanderbilt spokesman Jim Patterson said Kearse was stopped early Sunday morning after campus police reported seeing the SUV that Kearse was driving weaving across the road.
Patterson says Kearse took a field sobriety test, but refused a breathalyzer. He was arrested and charged with DUI and violation of Tennessee's implied consent law for failing to take the breathalyzer test. Officials said Kearse was released later in the morning.
A call to the Titans was not immediately returned. A spokesman for Kearse's agent, Drew Rosenhaus, said Kearse had no comment.
Kearse, the NFL Defensive Rookie of the Year in 1999 with the Titans, re-signed with the club in the offseason after spending the last four years with the Philadelphia Eagles.