Police say the mother was able to get out with one of the children, but was not able to get the other out.
Two police officers who arrived on the scene tried to rescue the other child, but without the proper equipement their rescue attempt was unsuccessful.
Soon, firefighters arrived, and they were able to get inside, and rescue the child.
Neighbor Charlene Kelly found herself choked up while talking to Action News about what she saw.
"We looked throught he fence, and they had this little boy on a stretcher," Kelly said. "And it looked like he was burned pretty bad."
The two children, ages two and five, were first taken to Cooper University Hospital, then flown by helicopter to St. Christopher's, where they are in critical condition.
The mother, Christine Holland, is in fair condition at Temple University Hospital. She is suffering from smoke inhalation and other injuries.
In addition, two police officers who arrived at the scene first were also slightly injured trying to help the Holland family. They were treated and released for smoke inhalation.
The fire marshal is investigating the cause of the fire.
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