Villanova ran for 317 yards behind Ball, Chris Whitney and Matthew Szczur.
Villanova scored twice in the final seven minutes of the second quarter to take control.
Whitney's 1-yard touchdown run capped a 10-play, 65-yard drive.
The Wildcats then stopped the Blue Hens on a fourth-and-1 at their 40. And Ball broke off a 51-yard touchdown run to give Villanova a 14-0 advantage.
Ball added a 1-yard touchdown run in the third quarter, finishing a seven-play, 62-yard drive.
