An administration said that Gupta had been under "serious consideration" but took himself out of the running because he wants to focus on his medical career and spend more time with his family.
"We know he will continue to serve and educate the public through his work with media and in the medical arena," said the official, speaking on condition of anonymity because of the sensitivity of nominations.
The official said there were no problems that would have disqualified Gupta, and it was his decision to withdraw.
The surgeon general is the nation's doctor, and while the job doesn't involve much policymaking responsibility, it's a bully pulpit for promoting public health. Gupta could have helped Obama pitch his health care reform plan.
Initial reports in early January that Obama had approached Gupta about the job created a stir. The new president had not yet taken office. The chairman of the American Medical Association's board said at the time it would be a boon to the government if Gupta accepted.
But Gupta would have had to give up a lucrative career. He hosts "House Call" on CNN, contributes reports to CBS News and writes a column for Time magazine. He also practices surgery at Atlanta's Grady Memorial Hospital, which sees more than its share of trauma cases.
Political opposition had started to form.
House Judiciary Committee Chairman John Conyers, D-Mich., called Gupta inexperienced and circulated a letter urging Obama not to appoint him. Conyers is a leading supporter of health care reform that would create a government system similar to Canada's, and is particularly influential among liberals.
Gupta does have some Washington experience. During the Clinton administration, he served as a White House fellow and a special adviser to then-first lady Hillary Clinton.
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