Martin Erat scored for the Predators, who missed a chance for the second-longest winning streak in franchise history. The Predators opened the 2005-06 season with eight straight wins.
Biron made spectacular glove saves on Erat while sprawled on his back midway through the first period, and on Ryan Jones and Jason Arnott on second-period power plays.
Richards put the Flyers ahead on a power play 45 seconds into the second period with a one-timer from the right circle that glanced off and then slid under goalie Pekka Rinne's pad.
Nashville had killed off 19 straight power plays over the past seven-plus games before Richards' goal.
Lupul made it 2-0 at 4:22 of the period when he took a cross-ice pass from Kimmo Tomonen and poked the puck off Rinne's blocker into the net.
Erat scored on a wrist shot from the slot at 7:45 of the third period, but Lupul put the Flyers ahead 3-1 just 1:06 later when he rebounded Daniel Carcillo's backhanded attempt into the goal.
It was the first Flyers' point for Carcillo, who was obtained from Phoenix in a trade for Scottie Upshall last Wednesday.
Carcillo, who went into the game leading the NHL with 174 penalty minutes, was called for his first infractions with the Flyers, a minor for unsportsmanlike conduct, and a major for fighting with Greg de Vries.
Giroux took advantage of a Nashville turnover to score from slot with 3:13 left.
Notes: Philadelphia C Daniel Briere was out after reinjuring his groin against Calgary on Thursday. ... The Predators had outscored their opponents 28-11 during their winning streak.
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