Oprah Winfrey is poised to send her very first "tweet" during her show Friday at 4pm on 6abc.
The talk show queen is dedicating Friday's show to the online social networking tool, Twitter.
More than 60-thousand people have already signed up to follow her.
Actor Ashton Kutcher will be a guest on the show.
He is the first person to reach one million followers on Twitter.
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