Biden, who has a reputation for off-the-cuff remarks, went beyond any precautions recommended by the federal government. In discussing his personal advice to his family, he said simply, "That's me."
Within two hours, Biden's office issued a statement backing off the remarks and suggesting he was talking about travel to Mexico.
"On the 'Today Show' this morning, the vice president was asked what he would tell a family member who was considering air travel to Mexico this week," said spokeswoman Elizabeth Alexander. "The advice he is giving family members is the same advice the administration is giving to all Americans: that they should avoid unnecessary air travel to and from Mexico. If they are sick, they should avoid airplanes and other confined public spaces, such as subways."
Biden, who has three grown children and five grandchildren, was asked whether he would advise his own family against flying to Mexico on a commercial flight.
"It's not just going to Mexico, if you're in a confined aircraft and one person sneezes it goes all the way through the aircraft," Biden said on NBC. "That's me. I would not be at this point, if they had another way of transportation, suggesting they ride the subway."
The Centers for Disease Control and Prevention recommends avoiding nonessential travel to Mexico. But it isn't recommending that people avoid other travel because of the swine flu.
American Airlines spokesman Tim Smith declined to comment directly on the vice president's remarks, but said, "To suggest that people not fly at this stage of things is a broad brush stroke bordering on fear mongering."
"The facts of the situation at this stage anyway certainly don't support that," Smith told The Associated Press.
U.S. Travel Association President Roger Dow urged the public to "heed the advice of medical experts" and gently chided the vice president without specifically mentioning him.
"Elected officials must strike a delicate balance of accurately and adequately informing citizens of health concerns without unduly discouraging travel and other important economic activity," Dow said in a statement Thursday.
During his decades as Delaware senator, Biden was a regular on Amtrak, riding the train from Wilmington to Washington.
Asked on NBC's "Today" show whether the U.S. government should close the border with Mexico, Biden said health authorities advise that would be impractical and noted the new flu is already in the U.S. and several other nations.
Instead, Biden said, the focus should be on slowing the spread of the virus through groups of people in close quarters, such as airplanes, malls, stadiums and classrooms.
"Closing the classroom and closing the border are two fundamentally different things," he said.
The CDC recommends basic precautions such as hand-washing, use of alcohol hand gels and monitoring local health advisories when traveling. The government also advises that children with the flu be kept home from school and day care. Biden said he hoped employers would be generous with workers who stayed home to care for a sick child.
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