Chase Utley hit his 10th homer and Raul Ibanez also went deep for the Phillies, who got another poor performance from a starting pitcher. Joe Blanton (1-3) gave up six runs and eight hits in eight innings.
Blanton's shaky start was the latest in a slew of rough outings for a rotation that played a vital role in helping the Phillies win the World Series last season. Philadelphia's starters are 7-10 with a 6.47 ERA.
Vazquez was hitless in his first 12 at-bats this season before lining a one-out double down the left-field line in the fifth. He scored on Kelly Johnson's double. Escobar followed with a drive to the seats in left-center for a 4-1 lead.
McCann, wearing glasses after missing 13 games with an eye infection, connected in the eighth to make it 6-1.
Ibanez hit one into the second deck in right field in the bottom half for his ninth homer.
Utley is off to another strong start. The All-Star second baseman belted 21 of his career-best 33 homers in the first 59 games last year, but hit only 12 in the final 103 games. He played through a hip injury, waiting until after the season to have surgery.
Jeff Francoeur lined an RBI single off the wall in left to give the Braves a 1-0 lead in the second.
Vazquez bounced back from two subpar starts. He gave up 11 runs in 14 2-3 innings against St. Louis and the New York Mets, losing both games.
Notes: The Phillies fell to 0-9 when they score three runs or less. They're 15-4 when they score at least four runs. ... Francoeur has a 10-game hitting streak. ... Braves CF Jordan Schafer is hitting .161 (5 for 31) with 17 strikeouts in his last eight games. ... Chipper Jones has a 29-game hitting streak against the Phillies. ... McCann is 6 for 7 with two homers and six RBIs against Blanton. ... Vazquez improved to 11-7 against the Phillies, beating them for the first time since Aug. 23, 2003, with the Montreal Expos.
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