Scientists are trying to answer that question.
Seven Burmese pythons have been dumped into a snake pit at the Savannah River Ecology Lab in South Carolina.
They're tagged with radio transmitters and data recording devices.
The researchers want to determine whether the snakes can survive in the Southeast.
All had been captured a few hundred miles south in Florida.
Scientists are worried about the number of pet pythons that escape or are intentionally released by their owners and whether they can make their way north.
But the researchers say the pythons at the lab aren't going anywhere -- they're behind 400 feet of reinforced fence.
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