Depp nudged aside Jackman to get the coveted endorsement from People magazine Wednesday. It's the 46-year-old actor's second time as "Sexiest Man Alive." He also won in 2003.
Kate Coyne, senior editor at People, said on CBS' "Early Show" that Depp has achieved an almost "iconic status in terms of sexiness."
Says Coyne: "Johnny Depp was someone who was sexy 10 years ago. He'll be sexy 10 years from now. He's someone who appeals to multiple generations of women."
Depp joins other double winners Brad Pitt, George Clooney and Richard Gere.
Matt Bomer, who stars in USA's "White Collar," was named "Sexiest Rising Star."