The Clippers blew a 16-point, third-quarter lead and nearly lost on Andre Iguodala's jumper as time expired in the fourth. The shot was waived off after it was ruled Iguodala did not get it off in time.
Marreese Speights scored 28 points and Iguodala added 20 for Philadelphia.
The game was played before a sparse crowd of about 2,600 at Wachovia Center who braved a winter storm that dumped one to two feet of snow in the area.
For the second straight night, the Clippers built a double-digit lead, but this time it held. They lost to the New York Knicks on Friday night after leading by 20 points.
The Sixers chipped away, trailing by five at the end of the third quarter before taking the lead late in the fourth.
Lou Williams returned to Philadelphia's lineup after missing 12 games with a broken jaw, scoring six points in 23 minutes. His ahead-of-schedule return was welcome news to a team that was again without newly acquired Allen Iverson, who missed his second straight game with arthritis in his left knee. Iverson had the knee drained twice this week.
