The all-star cast includes everyone from Jamie Foxx to Jennifer Garner. "Valentine's Day" could also set a Presidents Day weekend record.
Warner Bros. estimates it will be in the $60 million range for the holiday weekend, beating "Ghost Rider" from 2007.
It's a tight race for second place this weekend. "Percy Jackson & the Olympians: The Lightning Thief" has a slight edge over "The Wolfman."
"Avatar" drops to fourth.
