The Spurs have lost eight of their last 10 trips to Philadelphia, dating to the 1999-2000 season.
Andre Iguodala had 20 points, nine rebounds and eight assists for Philadelphia. Elton Brand added 18 and seven rebounds. The Sixers outscored the Spurs 33-18 in the final 12 minutes.
The Spurs received only a combined 12 points from Tim Duncan and Tony Parker. Parker finished just 1 for 9 from the field.
San Antonio led for much of the first three quarters because of Manu Ginobili, who scored a game-high 24 points on 9 for 18 shooting.