The accident happened shortly after 3:00 p.m. in the 400 block of Willowbend Court, in the West Riding neighborhood.
Preliminary reports say the driver may have suffered a medical condition causing him to drive through several yards before running into the home.
The driver was transported to Christiana Hospital with non-life-threatening injuries.
Residents were inside the home at the time, but were not injured.
Building inspectors are set to assess the damage.