It was a dismal display for Milwaukee, which had won 15 of the last 17 to virtually assure a postseason berth for the first time since 2006.
Instead, Samuel Dalembert had 12 points and 10 rebounds, Willie Green scored 16 points and Andre Iguodala 14 as the Sixers poured it on for their third win in the last 16 games.
Jerry Stackhouse scored 15 points and rookie Brandon Jennings added 12 for Milwaukee, but the Bucks shot 5 of 28 from 3-point range and led only once in the game, 3-0.
Milwaukee, in fifth place in the Eastern Conference, had last won eight straight at home during a 10-game streak in 2004, and its 15-2 record was its best stretch in 28 years.
But this squad that's made its reputation on tough defense and a grinding pace of play showed neither against the Sixers. Instead, the Bucks settled for long jump shots and allowed Philadelphia to score at will.
There was no need to "Fear the Deer" - the buzz phrase that's caught on here - because these Bucks looked exactly like the team that's won 38 percent of its games in the last five seasons and finished last in the Central Division each time.
John Salmons, who'd been averaging 20.5 points since a trade to Milwaukee at the deadline, went 2 of 12 for four points in 30 minutes after playing an average of 43½ minutes in the previous four games.
The Sixers, who were formally eliminated from the postseason after Monday's games, shot 52.6 percent from the field.
The lack of energy was never more apparent than midway through the third quarter, when Carlos Delfino lost the ball falling flat on his back in the lane. Iguodala took the outlet pass and found Dalembert for an easy dunk that gave this Sixers a 71-54 lead. A few minutes later, Stackhouse blocked a shot that earned cheers from the crowd, but Charlie Bell immediately lost the ball and Iguodala had a thunderous dunk that made it 81-63 to end the third.
By that point, the Sixers, in the midst of their worst season in over a decade, could've easily been up even more.
Jennings hit a 3-pointer to open the game, but Milwaukee never led again and missed its next 14 tries from beyond the arc.
NOTES: The game marked the first return of rookie Jodie Meeks, who was a second-round pick by the Bucks but was traded at the deadline to Philadelphia along with Francisco Elson for Primoz Brezec and Royal Ivey. Meeks had seven points in 21 minutes. ... Sixers G Lou Williams (lower back pain) missed his second straight game, while F Thaddeus Young (broken right thumb) missed his fifth in a row.