Toronto coughed up a 17-point third-quarter lead, but Bosh put the game away in overtime.
Rookie Jrue Holiday put Philadelphia up 114-111 with 59 seconds left, but Jose Calderon tied it 17 seconds later with a 3. Bosh had a chance to win the game, but missed a contested layup at the buzzer.
Philadelphia led 120-119 after Andre Iguodala's 3-pointer with 2:56 remaining in overtime.
The teams were tied at 122 before Bosh's layup moved the Raptors ahead. Philadelphia had a chance to tie it with 52 seconds left, but Sam Dalembert missed a free throw. Bosh drilled a bank shot to extend Toronto's lead to 126-123 after Iguodala missed a 3-pointer. Jarrett Jack's free throws with 14 seconds remaining clinched the victory.
Iguodala finished with 33 points and 11 assists, both season highs, to go with eight rebounds to help the Sixers stage their comeback. Holiday added a career-high 25 points for Philadelphia.
Toronto shot 16 for 21 from the floor in the third quarter and opened the fourth up 99-87, but the Sixers put together a 20-7 run to open the quarter. Willie Green's 19-foot jump shot with 3:59 remaining put Philadelphia ahead 107-106, the team's first lead since the second quarter. Green finished with 13 points.
Sonny Weems continued to have a hot hand for the Raptors, putting in 18 points on 9-of-11 shooting. He was 8 for 8 with 17 points in the Raptors' win over the Clippers on Wednesday. The Raptors' sharp shooting and Philadelphia's sloppy defense led to the Sixers going the entire quarter without an individual rebound.
NOTES: Lou Williams returned for the Sixers after missing five games with lower back pain. ... Toronto entered the game with a 1½-game lead over Chicago for the eighth and final playoff spot in the East. ... Philadelphia had just three team rebounds in the third quarter. ... Elton Brand had no rebounds in 25 minutes.
