Investigators say officers started to pursue the suspects about 2:30 Friday morning, after determining that the two men had just stolen construction equipment.
During the police chase, officers say the suspects threw the stolen equipment at the police cruiser.
Some of the equipment hit the cruiser but did not cause any injuries to the officers.
The suspects' car then crashed on Route 309 just south of Route 113.
The two men jumped out of the car and made a run for it.
Officers shut down a stretch of 309 and used police dogs to try to track down the suspects.
But the two men remain on the loose.