The nude peep show is known for the naughty puns on its marquee.
The sign currently plays off two movies, "The Skirt Locker" and "Clash of the Tight Buns."
The Lusty Lady is also female-owned and shares profits with the dancers.
The strip club has been around since the 1970s.
Manager Deborah Seaver says the slumping economy is to blame for the Lusty Lady's demise.
It will close this summer.