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Rock Hill police say the victim told officers that he argued Tuesday night with 29-year-old Tony Smith over loud music coming from Smith's room.
The dispute appeared to be over, but the man told police Smith walked up to him several hours later with a 4-foot python and hit him in the face with the snake's head.
Smith surrendered the snake to family members before police handcuffed him and took him to jail.
Smith was charged with assault and battery. He remains in the Rock Hill jail on a nearly $1,100 bond and jail officials did not know if he had an attorney.
