At least 3 people were sent to the hospital.
The fire occurred around 1:45 a.m. to the apartment building located at 401 West Walnut Lane. Crews encountered flames shooting from one of the apartments on the second floor that spread to an adjoining apartment.
Thick black smoke went throughout the apartment building and forced firefighters to evacuate the entire building.
One woman in her 50's was rescued by firefighters and taken to Temple University Hospital in serious condition with smoke inhalation.
A male in his 50s was taken to Albert Einstein Medical Center with smoke inhalation and is listed in stable condition.
A third woman suffering from smoke inhalation was also taken to Einstein.
The Philadelphia Fire Marshal's Office along with Philadelphia Police are investigating.