It happened Wednesday about 12:35 p.m. at Louviers Drive and Paper Mill Road. Rescue workers had to extricate two women from the same car.
The driver was pronounced dead at the scene. A female passenger was freed after 15 minutes and taken to Christiana Hospital, where she was in critical conditions with head and internal injuries.
A man in the second car refused medical treatment. The driver of the third vehicle was not injured.
The crash is under investigation.
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Information from: The News Journal of Wilmington, Del.