Wells, a sixth-round pick in 2003, has started 90 games in seven years with Arizona, including 64 in a row since late in the 2005 season.
The Eagles released cornerback Geoff Pope, who spent six weeks on the team's active roster last year and played in one game, and veteran running back J.J. Arrington.
Also released Friday were defensive end Pannell Egboh, defensive tackle Boo Robinson, cornerback David Pender, wide receiver Dobson Collins, tight end Nate Lawrie, offensive tackle Jeraill McCuller, safety Anthony Scirrotto and running back Martell Mallett.
