Shots rang out on the 3700 block of North 10th Street in Hunting Park around 12:40 a.m. Monday.
Police say two men in their 20s were leaving a Chinese restaurant when they were approached by two other men.
One of those men took out a gun and shot one victim in the head.
The second suspect began chasing the other victim, then shot him in the back.
Both suspects were last seen running south on Erie Street.
Police are searching for two males- one with a mustache, last seen wearing a blue and white striped shirt and jeans. The second suspect was last seen in all dark clothing, hooded sweatshirt and jeans.