The accident happened shortly before 8:00 a.m. when the driver struck the concrete median and then flipped several times. The vehicle then rolled across the southbound lanes and came to a stop on the shoulder.
The 28-year-old female driver was transported to Christiana Hospital with internal injuries.
All lanes of I-495 south were briefly closed as rescue crews respond to the scene. Police then kept one lane closed for about 1/2 hour.
Traffic has since reopened.
No word on if ice was a factor in the crash.