Show spokesman Rick Miramontez says Paul Bogaev will be working with U2's Bono and The Edge to improve the quality of music on the $65 million show.
Bogaev was musical director on Andrew Lloyd Webber's "Starlight Express" and "Sunset Boulevard."
"Spider-Man" is set to open March 15. It has been delayed several times, had a main actress quit and suffered numerous accidents that have left several actors hospitalized.
Bogaev won a Tony nomination in 2004 for his work on "Bombay Dreams." He has a history of working with rock musicians who are crafting musicals, including "Tarzan" with Phil Collins and "Aida" with Elton John.