The accident occurred around 4:50 Sunday morning on the Girard Point Bridge.
Police say Megan Bredell of Gibbsboro was travelling southbound in the northbound lanes of the highway when her 2007 Ford Fusion plowed into a Toyota Corolla.
Bredell, a passenger in her car and the operator of the other vehicle involved, were all hospitalized.
Police say Bredell displayed signs of intoxication. Chemical tests were conducted and results are pending.
Criminal charges related to the crash are also pending.