Reports of flames came in just before 5 a.m. along the 1700 block of Larchwood Drive, which is off of Township Line Road in Whitpain Township.
Firefighters reported heavy fire on the 2nd floor of the house and flames in the garage and basement of the building.
While they were on the scene, evacuation tones sounded for firefighters get out of the burning building. So far, there are no reports of injuries.
Police have closed Township Line Road between Arch Street and Sheffield Drive.