The tractor trailer, being driven west on 422, jack-knifed and crashed through the median around 9:00 a.m.
The gasoline tanks of the truck were punctured in the crash.
It happened just before the Lancaster Ave exit.
The driver of the tractor trailer was transported to a hospital as a precaution.
There is no word yet on how this crash happened.
The highway was reopened again on Tuesday afternoon.