The company says it is making a concerted effort to add staff as its business improves and as more of its restaurants stay open 24 hours a day.
The company's hiring goal translates to between three and four new hires per restaurant.
McDonald's says turnover slowed because of the weak economy. The company sees an opportunity to attract employees in a tough job market.
McDonald's held a similar event in its Western region last year. More than 60,000 people applied for the 13,000 positions.
Those who are interested can apply in stores or online. Some restaurants will hold events and interviews that day.
McDonald's is based in Oak Brook, Ill.