Around 9:00 p.m., police were called to 51st and Irving streets.
Police say a 25-year-old male was shot a total of four times. He suffered two gunshot wounds to the chest, one in the leg, and one in the wrist.
The victim was taken to the Hospital of the University of Pennsylvania.
He was pronounced dead shortly thereafter.
The shooter, described only as a man, fled the scene on foot and remains at large.
There is no word on a motive for the shooting.