Crews were called to the 3100 block of Orthodox Street near the Betsy Ross Bridge.
Chopper 6 showed thick black smoke billowing into the air.
A second alarm was sounded as of 4:04pm, and a third alarm 17 minutes later.
The fire was brought under control at 5:10 p.m.
No injuries have been reported.
There is no word yet on what sparked the blaze.