The crash happened in the northbound lanes of the highway in Upper Chichester.
The view from Chopper 6 HD showed the truck, a flatbed, with serious damage to the cab.
A heavily-damaged blue car could also be seen.
The items being carried by the truck were spilled all over the highway.
There is no word yet on what caused the crash.
Traffic was being diverted off the highway for most of the afternoon, but all lanes have since reopened.