The crash happened around 7:00 p.m. Thursday at the intersection of 5th and Robeson Streets in Reading.
The officer's cruiser swerved off the road and into the side of a nearby garage.
"He [the officer] fell to the curb, and that's when everybody came over to him because he was really bleeding profusely from the head," said Lisa Cruz, an eyewitness to the accident.
Investigators say the police officer was rushed to Reading Hospital and is expected to be okay.
"He has a laceration on top of his head, and lots of bumps and bruises," said Lt. David Shilling. "He's awake and talking and fully coherent."
Police say the passengers in the other vehicle were all responsive and expected to be okay. One of them was taken away on a stretcher.
Investigators say the officer was actually trying to get to 5th and Buttonwood Streets to assist other officers who were making an arrest in a domestic dispute.
There, police say a husband had shot at his wife several times. Police confirm no one was hit during the shooting, and the husband is currently in police custody.
This is the second car accident involving a Reading police cruiser in just under two months.
The previous accident happened on April 15th on the Bingaman Street Bridge in Reading. Berks County detectives are investigating. District Attorney John Adams says the results from the April 15th police-involved car crash are expected to be released in about 10 days.