It happened at 2:15 p.m. on Sicklerville Road between Jarvis and Garwood Roads.
Video from Chopper 6 HD showed two SUVs being loaded onto flatbed tow trucks.
Both had sustained heavy front end damage.
Four people were rushed to area hospitals, at least one with serious injuries.
The victims names have not yet been released.
Police said Sicklerville Road will be closed for several hours as the investigation continues.