Investigators were called to the 500 block of Felton Avenue around 11:00 p.m. Thursday.
Police say three brothers were outside their home when a group of unknown males walked past.
Heated words let to a fight, police say, and a 16-year-old brother suffered stab wounds to the back and chest. Another brother, Josh Williford, was stabbed in the right bicep.
Both were taken to the hospital, but there has been no further word on their conditions.
Police say they only have a vague description of the suspects.
Anyone with information in regards to this incident is asked to contact Detective Dan Leicht or the Collingdale Police Department at 610-586-0502.