The crash happened around 10:00 a.m. at the intersection of Tomlin Station Road and Woodland Avenue in Harrison Township.
Both were taken to area hospitals. One victim was even flown by helicopter.
However, authorities said the bicyclists' injuries are not life-threatening.
Police say the driver did stop at the scene and there have been no charges filed at this time.
There is no word yet on the identities of those involved.