Louis "Luigi" Borda is leaving for Harrisburg on Thursday. The 45-year-old marathoner hopes to run about 25 miles a day and will be tailed by a motorhome.
Borda wants education supporters from other school districts to join him as he passes through their communities.
Gov. Tom Corbett has proposed more than $1 billion in education cuts to close a budget gap. Lawmakers have yet to approve his plan.
Borda, who teaches geography and social studies at the Masterman school, is not the first person to run for education.
Athletes from at least two state universities ran to Harrisburg in March to protest proposed cuts to their institutions.