This is their 12th annual reunion where relatives travel from all over.
Tomorrow, Joseph Carnuccio will save the life of his brother Frank by giving him a kidney.
"I couldn't sit back and know I'm healthy, I'm able to give a kidney," Joseph said.
Frank couldn't find a match in his family.
So his brother Joseph entered a program through Thomas Jefferson University Hospital and volunteered to donate his kidney to a stranger.
In return, Frank received a kidney from an anonymous donor earlier this month and is recovering at home.
"It's a good deal, my brother gets a kidney, it saves his life; I donate a kidney and save someone else's life. How great is that?" Joseph said.
This was Frank's second time getting a kidney.
17 years ago, his other brother Larry gave him the vital organ. Talk about brotherly love.
"It was a little uneasy feeling, but I never waiver in my commitment to do it; I was happy to do it," Larry said.
Joseph says his donation tomorrow is what family is all about.
"With my family and the love and Jesus Christ leading the way, I can't ask for anything more," Joseph said.
Joseph who lives in California will report to the hospital early Wednesday morning for his surgery. Recovery will take a few weeks so he won't be able to travel back home for another month.