The crash happened around 9:00 p.m. at North Broad Street and West Hunting Park Avenue.
Highway patrol officers were in pursuit of a suspect and caught up with him at 15th and Wingohocking. The officers had called for assistance because the suspect was trying to make a run for it on foot.
The 25th District cruiser was responding to the scene, travelling northbound on Broad, when it came into contact with a Jeep travelling in the same direction.
"The police vehicle ended up going into the northeast corner of Broad and Hunting Park, striking some fixed objects - a pole and a fence," said Lt. Ray Evers of the Philadelphia police.
The occupants of the Jeep were not injured.
The female officer who was driving suffered head, neck, knee and arm injuries. The male officer in the car suffered two possible broken legs and a broken arm.
"They're injured, but it's not life-threatening, so that's what's important," said Philadelphia Police Commissioner Charles Ramsey. "We'll sort everything else out.
Police said that at the initial vehicle stop, one person was arrested and another was being sought. There is no word yet on why they were being sought.
An investigation into how this crash happened continues.