The accident happened around 5:00 a.m. Sunday near the Route 476 split.
Police say 25-year-old Stanley Youman from Philadelphia was travelling northbound on I-95 when he lost control of his motorcycle.
Police say the motorcycle struck a guardrail and the impact of the crash ejected Youman from the bike onto the right shoulder.
He was taken to Crozer Chester Medical Center with serious injuries.
Police shut down two lanes of I-95 South as they conducted their investigation.