Miller led off the bottom of the first inning with a drive to the hill packed with fans behind the right-field wall. Pennsylvania tacked on seven more runs in the second, more than enough cushion for Breon.
"You lead off a game like that and you can't help to get pumped up. The roar of the crowd was amazing as he was rounding the bases," Pennsylvania manager Bill Garbrick said.
The partisan fans saluted the Keystone Little League all-stars from Clinton County with chants of "Keystone! Keystone!" following their latest victory. They play home games just 30 miles from South Williamsport.
Breon struck out two and walked three before Miller came on for the last two outs. The game ended after the top of the fourth due to Little League's 10-run rule.
Catcher Wyatt Koch credited Miller's homer with providing the spark his team needed with Pennsylvania facing elimination.
"It does take the pressure off," the 13-year-old Koch said. "It gets you motivated to get more runs and it helps the pitcher get a lead."
Pennsylvania faces Georgia on Tuesday.
After beating Georgia in its series opener on Thursday night, Louisiana lost its last two and was eliminated.
"Our big focus was to come in and hit the ball, no matter how much they hit. We just didn't get it done," manager Leland Padgett said. "I don't know what happened (to our bats). It's beyond me."