The accident happened around 4:30 a.m. on the northbound lanes of the Turnpike near Exit 4 in Mount Laurel, Burlington County.
Police say the collision sent the motor home off the highway and onto its side.
The two occupants of the motor home, from Pluckemin, N.J., were transported to an area hospital for non-life-threatening injuries.
There is no word on what led to the crash.
