The truck, which was hauling glass, overturned around 4:30 a.m. Monday along eastbound Route 49 in Pennsville.
According to police, the driver lost control at Ferry Road, causing the tractor-trailer to tip onto its side, taking down utility poles and just missing a commercial building.
The driver was able to extricate himself from the cab and was not seriously injured.
Route 49 is closed in both directions at this hour.