The crash happened just before 11:30 p.m. Sunday on the 2300 block of Front Street.
Police say 53-year-old Clifford Jorden, of the 6900 block of Woodland Avenue, was thrown from the motorcycle when the bike struck a pillar supporting the EL.
He was rushed to Temple University Hospital but was pronounced dead a short time later.
There is no word on what led Jorden to lose control of the motorcycle.