It happened just after 9:00 a.m. near mile marker 9 in Woolwich Township, Gloucester County.
New Jersey State Police tell Action News the big rig loaded with packages overturned on the northbound side.
The crash caused the cab and trailer to become separated and the trailer portion travelled across the northbound lanes and came to rest on the southbound side.
No serious injuries were reported in the accident.
Traffic was halted in both directions as crews worked to clean up debris and clear the scene..
Both sides of the turnpike were back open and traffic was flowing smoothly again by 10:30 a.m.